department AIIMS Guwahati

About Department
Faculty Members

The Department of Biochemistry commenced its services since the inception of the Institute in January 2021. The vision of the Department is to develop into a state-of-the-art facility that caters to the three-pronged approach adopted by the AIIMS institutions viz. Education, Patient Care, and Research. The Department plans to achieve this in the following manner:

1. Education

The Department is committed to nurturing students with advancements in Medical Biochemistry and Molecular Medicine, and to inculcate in them scientific curiosity, critical thinking, ethical attitudes, and practical skills. The Department has commenced MBBS teaching from January 2021, MD (Biochemistry) from January 2024, and PhD (Biochemistry) from July 2024 session onwards. The Department also provides specialized training for courses in allied specialties and envisions expanding the academic program to include interdisciplinary collaborations, and additional postgraduate courses to meet the evolving needs of the medical and scientific community. The Department also conducts Workshops and Continuing Medical Education (CMEs) on the latest advancements in the field at regular intervals.

2. Patient care

The Department is actively supporting the Institute in patient care by providing the latest laboratory facilities to aid in diagnosis, monitoring, and prognosis. Currently, the Clinical Chemistry Laboratory and the Immunoassay Laboratory of the Department provide examination of more than 100 laboratory parameters on a routine basis. The Department aims to expand the services to incorporate sophisticated biomarker testing involving molecular diagnostics, genomics, and proteomics. The Department also emphasizes providing primordial and primary screening facilities for the diseases prevalent in the community. The Department has also commenced the process of obtaining NABL accreditation for its clinical laboratory examinations.

3. Research

The Department is committed to perform health-oriented research and basic science research in the diverse fields of biomedical research such as cancer biology, cardiovascular diseases, neurobiology, metabolic diseases, molecular pharmacology, genomics, transcriptomics, medical genetics, molecular biophysics, data mining, etc. The Department carries out research in the forms of extramural funded projects, intramural research grant supported projects, MD and PhD theses, and independent faculty and student projects. The Department has also established collaborations with academic and research institutes engaged in multidisciplinary research across the country.

Current Staff

Faculty - 06
Senior Residents (Non-academic) - 03
Junior Residents (Academic)/ MD Biochemistry students - 02
PhD Scholars - 02
Junior Residents (Non-academic) - 01
Laboratory Technicians (Regular) - 03
Laboratory Attendants (Regular) - 02
Laboratory Technicians (Contractual) - 08
Laboratory Attendants (Contractual) - 02
Nursing Officers - 02
Data Entry Operator - 01

Faculty:

Prof. Subash C Gupta	Professor and Head
Dr. Indrajit Nath	Additional Professor
Dr. Jayanta Das	Associate Professor
Dr. Ashikh Seethy	Assistant Professor
Dr. Chandan Kumar Nath	Assistant Professor
Dr. Amit Kumar Sonkar	Assistant Professor

Residents:

Dr. Bidyut Bhuyan	Senior Resident (Non-academic)
Dr. Lanu Mona Aimol	Senior Resident (Non-academic)
Dr. Krishnarjuna Bankala	Senior Resident (Non-academic)
Dr. Leary Nampui	Junior Resident (Academic)/ MD Student
Dr. Ayesha Siddiqui	Junior Resident (Academic)/ MD Student
Dr. Imsuonen	Junior Resident (Non-academic)

PhD Scholars:

Mr. Arindam Dutta	Guide: Prof. Subash C Gupta
Mr. Lalramtluanga	Guide: Dr. Amit Kumar Sonkar

Research Projects

Ongoing/ Approved

Targeting triple negative breast cancer by engineering agents derived from Piper longum; Funding Agency: ICMR, India; PI: Prof. Subash Gupta; Total Budget: INR 73,60,717.00; Period: 2024-27
ICMR’s ‘Taskforce on Establishment of Reference Intervals in Indian Population’ (TERIIP); Funding Agency: ICMR, India; PI: Dr. Ashikh Seethy
Identification and characterization of stem cells phenotype in the oral cancer; Funding Agency: AIIMS Guwahati (Intramural Research Grant); PI: Prof. Subash Gupta
An analysis of the immunoinflammatory status of patients with autoimmune hypothyroidism with metabolic syndrome; Funding Agency: AIIMS Guwahati (Intramural Research Grant); PI: Dr Indrajit Nath
Drug related Biochemical alterations: A Biochemistry laboratory-based causality assessment study; Funding Agency: AIIMS Guwahati (Intramural Research Grant); PI: Dr Jayanta Das
Biochemical and Biophysical Characterization of Alanine Racemase for Identification and Development of Potential Antimycobacterial Drugs; AIIMS Guwahati (Intramural Research Grant); PI: Dr. Amit Kumar Sonkar
Performance characteristics of Glycated Haemoglobin estimation in blood samples by ion exchange chromatography using Sodium fluoride vial compared to standard EDTA anticoagulant; Funding Agency: AIIMS Guwahati (Intramural Research Grant); PI: Dr. Chandan Kumar Nath
Phased globin gene sequencing to decipher genomic variants in cis in Hemoglobin E disorders; Funding Agency: AIIMS Guwahati (Intramural Research Grant); PI: Dr. Ashikh Seethy
A study on the expression of long non-coding RNAs and metabolic profile in oral cancer; MD thesis (Dr Leary Nampui), Guide: Prof. Subash Gupta
A study on the association of long non-coding RNAs expression with cellular metabolites in head and neck cancer; PhD thesis (Mr Arindam Dutta); Guide: Prof. Subash Gupta
Association of NFKB1 polymorphism with inflammatory markers and C-terminal agrin fragments in patients with type 2 diabetes and sarcopenia; MD thesis (Dr Ayesha Siddiqui), Guide: Dr Indrajit Nath

Completed

Targeting long non-coding RNAs by agents derived from Moringa oleifera for breast cancer therapy; Funding Agency: ICMR, India; PI: Prof. Subash Gupta; Total Budget: INR 38,00,000.00; Period: 2020-23.
An In-silico Analysis of Genetic Alterations of Human Pseudo-autosomal Regions in Acute Myeloid Leukemia; Funding Agency: ICMR, India (STS Project); Mentor: Dr. Ashikh Seethy; Period: 2022-23.
Computational analysis of the role of nuclear insertions of mitochondrial origin (NUMTs) in the genesis of pathogenic variants in monogenic disorders; Funding Agency: ICMR, India (STS Project); Mentor: Dr. Ashikh Seethy; Period: 2023-24.

CMEs/ Workshops/ Other Events Organised

2024

CME on Multi-Disciplinary Approach for Cancer Management on the occasion of World Cancer Day, organised by Department of Biochemistry in collaboration with Departments of Pathology & Lab Medicine, Radiodiagnosis & Interventional Radiology, Obstetrics & Gynecology, Radiation Oncology, & Medical Oncology/Hematology, AIIMS Guwahati - February 06, 2024.
CME cum Workshop on Best Practices in Sample Collection, organised by Departments of Pathology and Lab Medicine, Biochemistry, Transfusion Medicine, and Microbiology – AIIMS Guwahati in collaboration with BD India Pvt Ltd. (Specimen Management Division) for celebration of the Phlebotomists Recognition Week - February 17, 2024.
Observance of National Science Day 2024, organised by Department of Biochemistry in collaboration with Departments of Anatomy & Physiology AIIMS Guwahati - February 28, 2024.
CME on Current Trends in OMICS - August 12, 2024.
CME cum Workshop on Quality Control (QC) Analytics and Six Sigma Methodology in Lab Medicine - November 09, 2024.

2023

CME on Cancer Scenario in Northeast India on the occasion of World Cancer Day, organised by Department of Biochemistry in collaboration with Departments of Pathology & Lab Medicine, Radiodiagnosis & Interventional Radiology, Obstetrics & Gynecology, Radiation Oncology, & Medical Oncology/Hematology, AIIMS Guwahati - February 04, 2023.
Observance of National Science Day 2023, organised by Department of Biochemistry, AIIMS Guwahati - February 28, 2023.
Workshop on Research Grant Writing, organized by Department of Biochemistry and Research Cell – AIIMS Guwahati - March 17 2023
CME cum Workshop on Best Practices in Sample Collection, organised by Departments of Biochemistry, Pathology and Lab Medicine, Transfusion Medicine, and Microbiology – AIIMS Guwahati in collaboration with BD India Pvt Ltd. (Specimen Management Division) - September 23, 2023
CME on Good Laboratory Practices & Essentials of Quality Control in Clinical Chemistry, organised by Department of Biochemistry, AIIMS Guwahati - December 09, 2023

2021

Invited lecture on DNA Technology and Nanotechnology: Will these Change the Future of Medical Science? organised by Department of Biochemistry, AIIMS Guwahati - July 14, 2021

Instrumentation

Thermal Cycler (Gradient PCR)	Flow Cytometer	Chemiluminescence-based Gel-imaging System	Immunofluorescence microscope	Fluorometer
Multimode Reader	ELISA Plate Washer	Refrigerated Centrifuge	Orbital shaker	CO₂ Incubator
Laminar Flow Hood	BSL-2 Biosafety Cabinet	Transfer System for Western Blot	Fully automated high-throughput clinical chemistry analyser (dry chemistry)	Semi-auto-analyser
HPLC for hemoglobin typing and HbA1c	ELISA Reader	Transilluminator	Lyophlizer	Deep freezers (-20 and -80 degrees)
Water Purification System	Gel Electrophoresis System	Spectrophotometer	pH Meter	Ice Flaking Machine
Flurometer	Electrolyte analyser

Services Available

Clinical Chemistry

Plasma glucose	Glucose tolerance test (GTT)	Calcium	Phosphorous	Uric acid
Serum electrolytes (sodium, potassium, chloride)	Lipid Profile (total cholesterol, trigylcerides, LDL, HDL, Cholesterol:HDL ratio)	Kidney function tests (creatinine, serum urea)	Liver tests (total bilirubin, direct bilirubin, indirect bilirubin, total protein, albumin, globulins, AG ratio, alkaline phosphatase, AST, ALT, GGT)	Creatine kinase (CK) (Total)
CK-2/ CK-MB	Magnesium	Amylase	Lipase	Serum iron
C-reactive protein (Quantitative)	HbA1c (HPLC)	HbA1c (enzymatic)LDH	LDH	Spot urine sodium
Spot urine potassium	Urine random calcium	Urine random magnesium	24 hour urine calcium	Urine random phosphorus
24 hour urine protein	Spot urine chloride	Urine random creatinine	Serum osmolality	Urine osmolality
Urine random uric acid	Urine random albumin	24 hour urine creatinine clearance	Urine albumin creatinine ratio (UACR)	Fluid electrolytes (sodium, potassium, chloride)
Serum homocysteine	Serum lithium	Transferrin saturation	Direct total iron-binding capacity (dTIBC)	Serum-pleural effusion albumin gradient (SPAG)
Synovial fluid analysis (glucose, protein, LDH, uric acid)	Fluid glucose, LDH, albumin, uric acid, protein, amylase, lipase	CSF analysis (glucose, protein)	Pleural fluid analysis (glucose, protein, LDH)	Serum-ascites albumin gradient (SAAG)
Rheumatoid Factor (RF)	Neonatal bilirubin (NBil)	Creatinine clearance	CSF Adenosine Deaminase (ADA)	Oral GTT DIPSI
Serum Adenosine Deaminase(ADA)	Urine protein creatinine ratio(UPCR)	Glucose-6 Phosphate Dehydrogenase (G-6-PD)

Immunoassay

Free T3 (fT3)	Free T4 (fT4)	Thyroid stimulating hormone (TSH)	Total T3 (T3)	Total T4 (T4)
Ferritin	25-OH-vitamin D3	Vitamin B12	Prolactin	Follicle-stimulating hormone (FSH)
Luteinizing hormone (LH)	β-human chorionic gonadotropin (β-HCG)	Total PSA	Cortisol	Carcinoembryonic antigen (CEA)
Alpha fetoprotein (AFP)	Parathyroid hormone, intact (PTH)	Total testosterone	Insulin	C-peptide
Progesterone	Folate	NT-ProBNP	Free PSA	CA 19.9
CA 125	Trop I	Pro-calcitonin

Dr. Subash Chandra Gupta

Professor & Head of the Department

scgupta@aiimsguwahati.ac.in

Dr. Subash Chandra Gupta

Professor & Head of the Department

Biochemistry

Qualifications

Ph.D. (Biochemistry): IITR (CSIR) Lucknow and University of Lucknow, India (2008)

M.Sc. (Biochemistry): University of Lucknow, India (2001)

Email

scgupta@aiimsguwahati.ac.in

Research interests/ Areas of Expertise/ Brief profile

Dr. Subash Gupta has contributed significantly to understanding the role of inflammatory pathways in cancer pathogenesis. His current research is focused on elucidating the role of long non-coding RNAs in the diagnosis and prognosis of cancer types such as breast cancer, head-and-neck cancer, gallbladder cancer, and glioblastoma. He has also been working to uncover the mechanism by which the acidic micro-environment contributes to cancer pathogenesis. He has published over 120 peer-reviewed articles in highly prestigious journals (total citations: >30,000; h index: 68; i10-index: 116; cumulative impact factor: 816.436; average impact factor: 6.53).

Google Scholar link: https://scholar.google.com/citations?user=tCzrPS0AAAAJ&hl=en

ORCID id: https://orcid.org/0000-0002-0418-1940

ResearchGate link: https://www.researchgate.net/scientific-contributions/Subash-Chandra-Gupta-2119079541

Memberships

1. The National Academy of Sciences, India.

2. Indian Academy of Biomedical Sciences, India.

3. American Association for Cancer Research.

4. Society for Nutraceuticals and Chronic Diseases, India.

5. Indian Society of Cell Biology.

1. Travel Award for attending "The Liver Week” in Seoul, Korea (2024).

2. Placed among the top 2% world scientists (list prepared by Stanford University, USA): 2021, 2022, 2023, 2024.

3. Highly Cited Researcher, Web of Science Group, Clarivate Analytics (2019, 2020).

4. Most Productive Researcher Award, Institute of Science, Banaras Hindu University, India (2018, 2019).

5. Shri Om Prakash Sharma Award, Indian Academy of Biomedical Sciences, India (2019).

6. Early Career Research Award by Science and Engineering Research Board, India (2016).

7. Dr. Prem Nath Wahi Award by Indian Council of Medical Research, India (2015).

8. AAPS Journal Manuscript Award (2015).

9. Novartis Oration Award by Indian Council of Medical Research, India (2014).

10. National Eligibility Test (CSIR-UGC-NET) by University Grants Commission, India (2003).

11. Junior Research Fellowship by Council of Scientific and Industrial Research, India (2002).

12. Junior Research Fellowship by Indian Council of Medical Research, India (2002).

Latest Publications

Latest Journal Articles (selected 10 publications in last 5 years)

1. Srivastava A, Mishra S, Avadhesh, Shekher A, Rai V, Dhasmana A, Das J, Perenzoni D, Iori R, Gupta SC. Moringin, an isothiocyanate modulates multiple cellular signalling molecules in breast cancer cells. Cellular Signalling 2024. in press. 2022 IF: 4.8.

2. Shekher A, Puneet, Awasthee N, Kumar U, Raj R, Kumar D, Gupta SC. Association of altered metabolic profiles and long non-coding RNAs expression with disease severity in Breast Cancer patients: Analysis by 1H NMR spectroscopy and RT-q-PCR. Metabolomics 19 (2023): 8. 2022 IF: 3.60.

3. Awasthee N, Shekher A, Rai V, Verma SS, Mishra S, Dhasmana A, Gupta SC. Piperlongumine, a piper alkaloid, enhances the efficacy of doxorubicin in breast cancer: Involvement of glucose import, ROS, NF-κB and lncRNAs. Apoptosis 27 (2022): 261-282. 2022 IF: 7.20.

4. Shekher A, Tiwari AK, Awasthee N, Verma SS, Dixit VK, Sinha N, Gupta SC, Puneet. Genes involved in phosphatidylcholine biosynthesis correlate with nuclear factor-kB in biliary tract cancer patients: Evidence from 1H-NMR and computational analyses. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids 1866 (2021): 158970. 2022 IF: 4.80.

5. Rai V, Aggarwal SK, Verma SS, Awasthee N, Dhasmana A, Aggarwal S, Das SN, Nair MS, Yadav S, Gupta SC. Epoxyazadiradione exhibits activities in head and neck squamous cell carcinoma by targeting multiple pathways. Apoptosis 25 (2020): 763-782. 2022 IF: 7.20.

6. Chava S, Reynolds PC, Pathania A, Gorantla S, Poluektova LY, Coulter DW, Gupta SC, Pandey MK, Challagundla KB. miR-15a-5p, miR-15b-5p, and miR-16-5p inhibit tumor progression by directly targeting MYCN in neuroblastoma. Molecular Oncology 14 (2020): 180-196. 2022 IF: 6.60.

7. Gupta SC, Awasthee N, Rai V, Gunda V, Chava S, Challagundla KB. Long non-coding RNAs and nuclear factor-kB crosstalk in cancer and other human diseases. Biochimica et Biophysica Acta-Reviews on Cancer 1873 (2020): 188316. 2022 IF: 11.20.

8. Verma SS, Rai V, Awasthee N, Dhasmana A, Rajalaksmi DS, Nair MS, Gupta SC. Isodeoxyelephantopin, a sesquiterpene lactone induces ROS generation, suppresses NF-kB activation, modulates lncRNA expression and exhibit activities against breast cancer. Scientific Reports 9 (2019): 17980. 2022 IF: 4.60.

9. Mishra S, Verma SS, Rai V, Awasthee N, Arya J, Maiti KK, Gupta SC. Curcuma raktakanda induces apoptosis and suppresses migration in cancer cells: Role of reactive oxygen species. Biomolecules 9 (2019): 4. 2022 IF: 5.50.

10. Awasthee N, Rai V, Verma SS, Francis KS, Nair MS, Gupta SC. Anti-cancer Activities of Bharangin Against Breast Cancer: Evidence for the Role of NF-kB and lncRNAs. Biochimica et Biophysica Acta-General Subjects 1862 (2018): 2738–2749. 2022 IF: 3.00.

Books

1. Clinical applications of non-coding RNAs in cancer. Publisher: Elsevier Inc; 2021; Page 1-459

2. Anti-inflammatory Nutraceuticals and Chronic Diseases. Series: Advances in Experimental Medicine and Biology; Publisher: Springer; 2016; Page 1-479.

3. Drug Discovery from Mother Nature. Series: Advances in Experimental Medicine and Biology; Publisher: Springer; 2016; Page 1-407.

4. Inflammation and Cancer. Series: Advances in Experimental Medicine and Biology; Publisher: Springer; 2014; Page 1-490.

Book chapters

Book chapters (selected 10 chapters in last 5 years)

1. Singh RD, Dholariya S, Shekher A, Avadhesh, Parchwani D, Gupta SC. Role of IL-1 gene polymorphisms in common solid cancers. In: Interleukin-1 Mediated Immune Suppression and Resistance to Immunotherapy in Cancer, edited by Singh M, Elsevier, 2022, Chapter 1, pp 1-78.

2. Awasthee N, Shekher A, Rai V, Baruah PK, Sharma A, Challagundla KB, Gupta SC. Clinical significance of long non-coding RNAs in breast cancer patients. In: Clinical applications of non-coding RNAs in cancer, edited by Gupta SC, Challagundla KB, Elsevier Inc., Cambridge, MA, USA, 2022, Chapter 8, pp 285-296.

3. Pathania AS, Smith OV, Prathipati P, Gupta SC, Challagundla KB. Clinical implications of non-coding RNAs in neuroblastoma patients. In: Clinical applications of non-coding RNAs in cancer, edited by Gupta SC, Challagundla KB, Elsevier Inc., Cambridge, MA, USA, 2022, Chapter 13, pp 409-431.

4. Chauhan HS, Rai V, Kini S, Shekher A, Sharma A, Gupta SC. Potential of long non-coding RNAs in the diagnosis and therapy of melanoma skin cancer. In: Skin cancer: Pathogenesis and Diagnosis, edited by Dwivedi A, Tripathi A, Ray RS, Singh AK, Springer Nature Singapore Pte Ltd, Singapore, 2021, Chapter 13, pp 217-250.

5. Dwivedi S, Verma SS, D’Souza C, Awasthi N, Sharma A, Gupta SC. Potential of Small Animals in Toxicity Testing: Hope from Small World. In: Biomarkers in Toxicology 2e, edited by Gupta RC, Elsevier Inc., San Diego, USA, 2019, Chapter 7, pp 129-142.

6. Verma SS, Rai V, Shukla KK, Gupta SC. Regulation of non-coding RNAs by phytochemicals for cancer therapy. In: Nutritional Epigenomics, edited by Ferguson BS, Elsevier Inc., San Diego, USA, 2019, Chapter 22, pp 371-380.

7. Sharma A, D’Souza C, Rai V, Gupta SC. Evaluation of safety and efficacy of nutraceuticals using Drosophila as an in vivo tool. In: Nutraceuticals in Veterinary Medicine, edited by Gupta R, Srivastava A, Lall R, Springer Press, Spring Street, NY, USA, 2019, pp 685-692.

8. Gupta SC, Sharma A, Mishra S, Awasthee N. Nutraceuticals for the Prevention and Cure of Cancer. In: Nutraceuticals in Veterinary Medicine, edited by Gupta R, Srivastava A, Lall R, Springer Press, Spring Street, NY, USA, 2019, pp 603-610.

9. Mishra S, Rai V, Kumar A, Aggarwal SK, Gupta SC. Molecular diagnostics in pancreatic cancer. In: Molecular Diagnostics in Cancer Patients, edited by Shukla K, Sharma P, Misra S, Springer Nature Singapore, 2019, pp 157-163.

10. Gupta SC, Rai V. Role of Emodin in Chemosensitization of Cancer. In: Role of Nutraceuticals in Cancer Chemosensitization, edited by Bharti AC and Aggarwal BB, Elsevier Inc., Philadelphia, USA, 2018, Chapter 12, pp 241-257.

Dr. Indrajit Nath

Additional Professor

indrajitnath@aiimsguwahati.ac.in

Dr. Indrajit Nath

Additional Professor

Biochemistry

Qualifications

MBBS, MD

Email

indrajitnath@aiimsguwahati.ac.in

Research interests/ Areas of Expertise/ Brief profile

Dr Indrajit Nath has a keen interest in the research related to non-communicable disease specially thyroid disorders, diabetes and cardiovascular disease (specifically in the field of metabolomics). He has a vast experience in laboratory medicine and was involved in the policy making for setting up of diagnostic facilities in the Government sector. His contributions extend to serving as a resource person for training and nurturing human resources in Clinical Biochemistry for the Government of West Bengal. Additionally, he has provided guidance and mentorship to several postgraduate students . He has also been a resource person for trainings in laboratory automation, indirect immunofluroscence, capillary electrophoresis,HPLC, and others.

Google Scholar link: https://scholar.google.com/citations?user=yhTqNEQAAAAJ&hl=en

ORCID id: https://orcid.org/0000-0002-6807-6736

ResearchGate link: https://www.researchgate.net/profile/Indrajit-Nath-3

Memberships

Life member of “Indian Medical Association”

Life member of “Association of Medical Biochemist of India".

Life member of Association of Clinical Chemistry and Laboratory Medicine Practitioner. (ACCLMP)”

Life member of “ All India Pre and Paraclinical Medicos Association.

Life member of ” Association of Medical Biochemist of Assam”

Life member of “ Association of Laboratory Consultants of North Bengal”

1. 1st prize in quiz competition in 17th AMBICON at Wardha,Maharashtra 2009.

2. 2nd position in poster presentation entitled “ Immunological aspects of Zinc and its Correlation with Viral Hepatitis” in National CME on Immunology organized by Indian Immunological Society at Agartala, Tripura.

3. Member(Medical Scientist) Ethics Committee of Assam Cancer Care Foundation (A Govt of Assam & TATA trust initiative),2023

4. Co-PI for the ICMR approved project on “Study of molecular profile of Nasopharyngeal carcinoma in the northeastern region and its relation to Epstein Barr Virus (EBV) infection” (Funding Agency: ICMR, New Delhi; PI: Dr Vandana Raphael – Dept. of Pathology, NEIGRIHMS, Shillong; Amount: Rs 1.18 crore. Duration: 2024-2027).

5. Technical Manager, Central Clinical Laboratory, Deptt of Biochemistry, NBMC under “Labs for Life Project”, a Partnership Project of Ministry of Health and Family Welfare and U.S Centers of Disease Control from 2017-2019.

6. NBE Appraiser for PG Entrance Examination, National Board of Examination 2019-2021

7. Organizing Secretary of “Dr. Asok Bandyopadhyay Memorial Oration & CME” on Immunity, Inflammation and Immunofluroscence” by Medical Education Unit, NBMC , Darjeeling. West Bengal,2022.

8. Organizing Chairman of CME on “Nutrition and Health-A Relation craving for more attention” by Association Of Laboratory Consultants of North Bengal, 2022.

9. Founder member and Assistant Secretary of Association of Laboratory Consultants of North Bengal (ALCON), 2020-2024.

10. Organizing Secretary of“ Pre Conference CME (ACCLMPCON-2024) on “ Breaking Barriers: Advancement in Alzheimer’s Disease” at NEIGRIHMS,Shillong,

Journal Articles

Shubhrajit Saha, Indrajit Nath, Mita S Das, Samarpita Mukherjee. A Study on Renal Function Status of Patients with Hypothyroidism attending a Tertiary Care Hospital in North Bengal. Indian Journal of Medical Biochemistry, January-June 2018;22(1):10-17.

Indrajit Nath, Swati Bhattacharyya and Mita Saha (Das). Study of Electrolyte status in patients with Thyroid dysfunction attending a tertiary care hospital of North Bengal. International Journal of Biomedical Research 2018; 09(02): 72-75.

Dr Suparna Dhara, Dr Indrajit Nath, Dr Anindya Dasgupta. Correlation between insulin resistance and pattern of dyslipidaemia in psoriasis. Paripex - Indian Journal of Research, March 2018; 7(3): 31-33.

P. Rajkhowa C.K Nath, B. Barman, P. Phukan, S. L. Sailo, B. Dey, I. Nath. Prostate-Specific Antigen Density: A Measurement to Differentiate Benign Hypertrophy of Prostate from Prostate Carcinoma. Journal of Laboratory Physician Mar 2020; 12(1):44-48.

S. Karmakar, K.C Sarkar, A. N Ray, I. Nath, A. Kumar, N. Arora. A study on association of hyperuricemia among patients of metabolic syndrome attending outpatient department of North Bengal Medical College and Hospital. Natl J Physiol Pharm Pharmacol 2020; 10(10): 874-877.

A Saha, P Mukhopadhyay, I Nath, A Kumar, UK Biswas. A quantitative assessment of body iron status and its relationship with glycemic control in patients of type 2 diabetes mellitus in a tertiary care hospital of Kolkata. Asian Journal of Medical Sciences 2021; 12(5):69-74.

S Pal, S Sen, I Nath, A Kumar, UK Biswas. Psoriasis, An inflammatory condition associated with oxidative stress. Asian Journal of Medical Sciences 2021; 12(4):24-30.

Dhiman Sardar, Swati Bhattacharyya, Indrajit Nath, Arup Kumar Banerjee, Ushasi Banerjee . A study to establish relationship of insulin resistance and anti thyroid peroxidase antibodies in hypothyroid patients of subhimalayan region of west Bengal. International Journal Of Scientific Research 2021; 10(1):40-43

Soutrik Roy , Indrajit Nath ,Sayantan Dasgupta , Arun Kumar , Utpal Kumar Biswas. Prevalence of variants haemoglobinand their effect on Hba1c measurement among the indigenous population of north Bengal attending a tertiary care hospital. Asian Journal of Medical Sciences 2022;13(6): 90-95.

SS Dutta, S Dasgupta, AK Banerjee, I Nath, U Biswas, N Bera, A Ruram. Exploring the Role of Serum Hydrogen Sulphide (H2S) Levels in Manic Depressive Psychosis in Terms of Its Association, Diagnostic Ability, and Severity Prediction: Findings From a Tertiary Care Center in North Bengal.2024;16(3)

Book chapters

Biochemistry MCQs for the online PG preparatory site MYPGMEE by Reed ELSEVIER India, 2014-2016.

Dr. Jayanta Das

Associate Professor

jayantadas@aiimsguwahati.ac.in

Dr. Jayanta Das

Associate Professor

Biochemistry

Qualifications

MBBS: 1998

MD: 2005

Email

jayantadas@aiimsguwahati.ac.in

Research interests/ Areas of Expertise/ Brief profile

Interested in clinical biochemistry and health-oriented research.

Memberships

Life member of Assam Chapter - Association of Medical Biochemists of India (AMBI).

1. Certificate of Appreciation for professional excellence at Dr. B. Borooah Cancer Institute, Assam (2009).

1. Jayanta Das, Dibyaratna Patgiri, Nirmali Mattack, Elteza Tahjiba Jahir. A Study on the Biological Reference Interval of Vitamin D in North-East India. National Journal of Laboratory Medicine. 2019 Apr, V0l-8(2): BO01-BO04.

Dr. Amit Kumar Sonkar

Assistant Professor

amitsonkar@aiimsguwahati.ac.in

Dr. Amit Kumar Sonkar

Assistant Professor

Biochemistry

Qualifications

M.Sc. (Biochemistry): University of Lucknow, India (2009) Ph.D. : CSIR-Central Drug Research Institute, Lucknow (2016)

Email

amitsonkar@aiimsguwahati.ac.in

Research interests/ Areas of Expertise/ Brief profile

Dr. Amit Kumar Sonkar conducts interdisciplinary research in molecular biology, bioinformatics, and structural biology. His work focuses on unraveling the molecular mechanisms of diseases through genomics, protein structure elucidation, enzymology, and molecular dynamics simulations. Dr. Sonkar's expertise lies in comprehensive genomic analyses to identify therapeutic targets, characterizing proteins to understand their roles in disease pathways, and investigating enzyme dynamics for drug development. He actively pursues drug discovery using computational methods, aiming to develop innovative therapeutic strategies. Through integration of experimental and computational approaches, Dr. Sonkar aims to advance understanding of complex biological systems and contribute to improved treatments.

Google Scholar link: https://scholar.google.com/citations?user=NFVNg24AAAAJ&hl=en

ORCID id: https://orcid.org/0000-0002-0981-1737

ResearchGate link: https://www.researchgate.net/profile/Amit-Sonkar

LinkedIn: https://www.linkedin.com/in/dr-amit-sonkar-24a9887a/

Memberships

Life member of Society of Biological Chemists, India
Life Member of Bioinformatics and Drug Discovery Society (BIDDS), India

DS Kothari Fellowship (DSKPDF) awarded by UGC, Govt. of India
Best Poster presentation prize in 11th National Symposium cum Workshop on "Recent Trends in Structural Bioinformatics and Computer Aided Drug Design" [SBCADD'2019] and 2nd Annual Meeting of Bioinformatics and Drug Discovery Society [BIDDS] held on 12th to 15th February at Department of bioinformatics, Alagappa University, Karaikudi, Tamilnadu.
Received EMBO travel grant to attend conference in “Gene transcription in yeast: from global analyses to single cells” held on 09 – 14 June 2018 at Sant Feliu de Guixols, Spain.
SERB-National-Post Doctoral Fellow (N-PDF) awarded by DST, Govt. of India.
Awarded with Junior Research Fellowship from Council of Scientific and Industrial Research (CSIR), India, June 2009
Qualified for National Eligibility Test (NET) for Lectureship, June 2009

Latest Publications (selected 10 publications in last 5 years)

Lyngdoh DL, Shukla H, Sonkar A, Anupam R, Tripathi T: Portrait of the Intrinsically Disordered Side of the HTLV-1 Proteome. ACS Omega 2019, 4, 10003−10018
Sonkar A, Shukla H, Shukla R, Kalita J, Tripathi T: Unfolding of Acinetobacter baumannii MurA proceeds through a metastable intermediate: A combined spectroscopic and computational investigation. Int J Biol Macromol. 16;126:941-951, 2018 Dec
Sonkar A, Lyngdoh D, Shukla R, Shukla H, Tripathi T, Ahmed S: Point mutation A394E in the central intrinsic disordered region of Rna14 leads to chromosomal instability in fission yeast. Int J Biol Macromol 119: 785- 791
Shukla R, Shukla H, Sonkar A, Pandey T, Tripathi T: Structure-based screening and molecular dynamics simulations offer novel natural compounds as potential inhibitors of Mycobacterium tuberculosis isocitrate lyase. J Biomol Struct Dyn:1-13.
Shukla H*, Shukla R*, Sonkar A*, Tripathi T: Alterations in conformational topology and interaction dynamics caused by L418A mutation leads to activity loss of Mycobacterium tuberculosis isocitrate lyase. Biochem Biophys Res Commun 490:276-282. (*Contributed Equally)
Shukla H, Kumar R, Sonkar A, Mitra K, Akhtar MS, Tripathi T: Salt-regulated reversible fibrillation of Mycobacterium tuberculosis isocitrate lyase: Concurrent restoration of structure and activity. Int J Biol Macromol 104:89-96.
Sonkar A, Gaurav S, Ahmed S: Fission yeast Ctf1, a cleavage and polyadenylation factor subunit is required for the maintenance of genomic integrity. Mol Genet Genomics.
Shukla H*, Shukla R*, Sonkar A*, Pandey T, Tripathi T: Distant Phe345 mutation compromises the stability and activity of Mycobacterium tuberculosis isocitrate lyase by modulating its structural flexibility. Sci Rep 7:1058. (*Contributed Equally)
Sonkar A, Shukla H, Shukla R, Kalita J, Pandey T, Tripathi T: UDP-N-Acetylglucosamine enolpyruvyl transferase (MurA) of Acinetobacter baumannii (AbMurA): Structural and functional properties. Int J Biol Macromol 97:106-114.
Sonkar A, Yadav S, Ahmed S: Cleavage and polyadenylation factor, Rna14 is an essential protein required for the maintenance of genomic integrity in fission yeast Schizosaccharomyces pombe. Biochim Biophys Acta 1863:189-197.

Book chapters

Sonkar AK, Khan S, Ahmed S. Synthetic Lethal Genetic Interaction Networks and Their Utility for Anticancer Therapy. In: Management of Microbial Resources in the Environment Editors: Abdul Malik, Elisabeth Grohmann, Madalena Alves, Springer, 2013.
Sharma N, Pandey H, Sonkar AK, Gondwal M, Singh S. Multimodal spectroscopic methods for the analysis of Carbohydrate. In: Advanced Spectroscopic methods to Study Biomolecular Structure and Dynamics, edited by Saudagar P and T Tripathi, Elsevier, 2023.
Sonkar A and Sonkar P. Potential role of nano phytochemicals in breast cancer therapy. In: Phytochemicals as an Epigenetic Modifier in Cancer Prevention, edited by Nidhi Puranik, Deepa Yadav and Sangeeta Shukla, IOP Publishing Ltd 2023.

Dr. Ashikh Seethy

Assistant Professor

ashikh.seethy@aiimsguwahati.ac.in

Dr. Ashikh Seethy

Assistant Professor

Biochemistry

Qualifications

MBBS: 2013 - Malankara Orthodox Syrian Church Medical College, Cochin

MD (Biochemistry): 2016 - Maulana Azad Medical College, New Delhi

DNB (Biochemistry): 2017 - National Board of Examinations, New Delhi

PhD (Biochemistry): 2022 - All India Institute of Medical Sciences, New Delhi

Email

ashikh.seethy@aiimsguwahati.ac.in

Research interests/ Areas of Expertise/ Brief profile

Dr. Ashikh Seethy has a research interest in genomics, medical genetics, hemato-oncology, and data mining. He is the Associate Editor and a chapter author of Lippincott Illustrated Reviews – Biochemistry, South Asian Edition. He is also a resource person in online courses like SWAYAM and e-PG-Pathshala by the Government of India. He is trained in advanced techniques like gene editing and next-generation sequencing and has been involved in Molecular Biology training as a part of numerous workshops. He is also passionate about conducting quiz competitions at National and State level events.

PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=ashikh+seethy&sort=date

ResearchGate: https://www.researchgate.net/profile/Ashikh-Seethy

Scholar: https://scholar.google.com/citations?user=6zAHBkAAAAAJ&hl=en

LinkedIn: https://www.linkedin.com/in/ashikhseethy/

ORCID: https://orcid.org/0000-0001-6825-5753

Memberships

1. Lifetime membership in American Association for Clinical Chemistry - India Session.

2. Lifetime membership in the Association of Clinical Chemistry & Lab Medicine Practitioners

3. Lifetime membership in Association of Clinical Biochemists of India.

4. Lifetime membership in India Society of Atherosclerosis Research – Delhi Chapter.

5. Membership in the Society of Young Scientists – AIIMS, New Delhi.

6. Lifetime membership in the Association of Medical Biochemists of India.

1. All India Rank-1 in the specialty of Biochemistry in the first attempt in the National Eligibility and Entrance Test for Medical Super Speciality Courses in India (NEET-SS) in June 2017.

2. All India Rank 7 in the specialty of Medical Genetics (DM/DNB-SS) in the National Eligibility and Entrance Test for Medical Super Speciality Courses in India (NEET-SS) in September 2020.

3. First place in FOUR national quiz competitions during residency: AMBICON – 2014 & 2015, ACBICON 2015, ISARCON 2019.

4. Best Oral Presentation Prize at the International Conference of Stem Cells and Cancer, Pune in October 2015 for the presentation titled ‘Tight Junction Protein, Claudin-6, is Downregulated in Human Breast Adenocarcinoma Cell Line, T47D and in Breast Cancer Tissues’.

5. Award Presentation Prize at the National Conference of Association of Medical Biochemists of India (AMBICON) in November 2015 for the paper titled ‘Decreased TET1 Mediated Hydroxymethylation of Promoter CpG Islands Causes Downregulation of Tight Junction Protein, Claudin-6 in Breast Adenocarcinoma Cells’.

6. Poster Presentation Prize at the National Conference of Association of Medical Biochemists of India (AMBICON) in December 2019 for the poster titled ‘What drives the progression of Myelodysplastic Syndromes to Acute Myeloid Leukemia?’

7. Quiz Master for 2 National-level and 7 State-level quiz competitions.

8. All India Rank-1 Ph.D. Program Entrance Exam, and Senior Residents Recruitment Exam (Biochemistry) by AIIMS-New Delhi, in July 2016.

9. Best Journal Club presentation award by the Department of Biochemistry, All India Institute of Medical Sciences, New Delhi for the year 2017.

10. Acknowledged as a Reviewer in the textbook ‘Biochemistry – Stryer': 8th ed and 9th ed, one of the most accepted textbooks in the subject.

Journal articles

Seethy AA, Pethusamy K, Kushwaha T, Kumar G, Talukdar J, Chaubey R, Sundaram UD, Mahapatra M, Saxena R, Dhar R, Inampudi KK, Karmakar S. Alterations of the expression of TET2 and DNA 5-hmC predict poor prognosis in Myelodysplastic Neoplasms. BMC Cancer. 2023 Oct 26;23(1):1035. doi: 10.1186/s12885-023-11449-2. PMID: 37884893
Seethy AA, Singh S, Mukherjee I, Pethusamy K, Purkayastha K, Sharma JB, et al. Potential SARS-CoV-2 interactions with proteins involved in trophoblast functions – An in-silico study. Placenta. 2021 Jan 1;103:141–51. PMID: 33126048
Seethy A, Pethusamy K, Chattopadhyay I, Sah R, Chopra A, Dhar R, et al. TETology: Epigenetic mastermind in action. Appl Biochem Biotechnol. 2021 Mar 10. doi: 10.1007/s12010-021-03537-5. PMID: 33694104
Pethusamy K, Seethy A*, Dhar R, Karmakar A, Chaudhary S, Bakhshi S, P JK, Chopra A, Chauhan SS, Karmakar S. Loss of TET2 with reduced genomic 5-hmC is associated with adverse-risk AML. Leuk Lymphoma. 2022 Sep 27:1-7. doi: 10.1080/10428194.2022.2126278. PMID: 36165590. *Equal contribution as first author.
Dhar R, Seethy A, Pethusamy K, Singh S, Rohil V, Purkayastha K, et al. De novo assembly of the Indian blue peacock (Pavo cristatus) genome using Oxford Nanopore technology and Illumina sequencing. Gigascience. 2019 01;8(5). PMID: 31077316
Dhar R, Seethy A, Singh S, Pethusamy K, Srivastava T, Talukdar J, Rath GK, Karmakar S. Cancer immunotherapy: Recent advances and challenges. J Cancer Res Ther. 2021 Jul-Sep;17(4):834-844. doi: 10.4103/jcrt.JCRT_1241_20. PMID: 34528529
Manhas J, Lohani J, Seethy A, Kumar U, Gamanagatti S, Sen S. Case Report: Characterisation of a rare pathogenic variant associated with loss of COL3A1 expression in vascular Ehlers Danlos Syndrome. Front Cardiovasc Med. 2022 Oct 11;9:939013. PMID: 36304539
Chattopadhyay I, Dhar R, Pethusamy K, Seethy A, Srivastava T, Sah R, Sharma J, Karmakar S. Exploring the Role of Gut Microbiome in Colon Cancer. Appl Biochem Biotechnol. 2021 Jan 25. doi: 10.1007/s12010-021-03498-9. PMID: 33492552
Dhar R, Pethusamy K, Singh S, Mukherjee I, Seethy A, Sengupta B, et al. Draft genome of Ompok bimaculatus (Pabda fish). BMC Res Notes. 2019 Dec 26;12(1):825. PMID: 31878964
Srinivasan K, Boulton CG, Bhattacharjee M, Sinha A, Loganathan S, Seethy A, Alam SM, Hanse B. Impact of heat stress on thermal balance, hydration and cortical response among outdoor workers in hot environment - an exploratory report from North East India. J Basic Clin Physiol Pharmacol. 2024 Mar 13;35(1-2):79-84. doi: 10.1515/jbcpp-2024-0003. PMID: 38468505.

Book chapters

Ashikh Seethy. Free Radicals, Oxidative Stress, and Antioxidant Defense Mechanism. In: Ferrier DR, Singh R, Goyal R, editors. Lippincott Illustrated Reviews: Biochemistry. SAE ed. New Delhi. Wolters Kluwer;2020.
Ashikh Seethy. Acid-Base Balance and Arterial Blood Gas (ABG) Analysis. In: Ferrier DR, Singh R, Goyal R, editors. Lippincott Illustrated Reviews: Biochemistry. SAE ed. New Delhi. Wolters Kluwer;2020.
Ashikh Seethy. Xenobiotics. In: Ferrier DR, Singh R, Goyal R, editors. Lippincott Illustrated Reviews: Biochemistry. SAE ed. New Delhi. Wolters Kluwer;2020.
Ashikh Seethy. Organ Function Tests. In: Ferrier DR, Singh R, Goyal R, editors. Lippincott Illustrated Reviews: Biochemistry. SAE ed. New Delhi. Wolters Kluwer;2020.
Ashikh Seethy. Water and Electrolyte Balance of Body Fluids. In: Ferrier DR, Singh R, Goyal R, editors. Lippincott Illustrated Reviews: Biochemistry. SAE ed. New Delhi. Wolters Kluwer;2020.
Ashikh Seethy. Ray PC. Cell Culture. In Bhat AA, Mir AR, editors. Quick Revision of Molecular Biology. New Delhi. Advance Research Publications; 2016.
Ashikh Seethy. Cellular Differentiation; Cellular and Molecular Biophysics. In PGPathshala-Biophysics. 2018. Accessible at http://epgp.inflibnet.ac.in/epgpdata/uploads/epgp_content/S001174BS/P001859/M030469/ET/1526645528P11_M08_ET.pdf
Ashikh Seethy. Aging and Longevity; Cellular and Molecular Biophysics. In PGPathshala-Biophysics. 2018. Accessible at: https://epgp.inflibnet.ac.in/view_f.php?category=1859
Ashikh Seethy. Sequencing Techniques of Nucleic Acids. In SWAYAM: Ministry of Human Resources Development - Government of India. 2019. Accessible at: https://swayam.gov.in/nd2_ugc19_bt16/preview.
Seethy A., Karmakar S., Pethusamy K. (2019) Ontogeny. In: Vonk J., Shackelford T. (eds) Encyclopedia of Animal Cognition and Behavior. Springer, Cham. DOI: https://doi.org/10.1007/978-3-319-47829-6_526-1. (Encyclopedia article)

Dr. Chandan Kumar Nath

Assistant Professor

chandannath@aiimsguwahati.ac.in

Dr. Chandan Kumar Nath

Assistant Professor

Biochemistry

Qualifications

MD: 2008

Email

chandannath@aiimsguwahati.ac.in

Research interests/ Areas of Expertise/ Brief profile

Diagnostic research.

Memberships

1. Life member of Association of Medical Biochemists of India (AMBI).

1. Nath CK, Barman B, Phukan P, Sailo SL, Dey B, Nath I, Rajkhowa P. Prostate-Specific Antigen Density: A Measurement to Differentiate Benign Hypertrophy of Prostate from Prostate Carcinoma. J Lab Physicians. 2020 Mar;12(1):44-48.

2. Hajong R, Newme K, Nath CK, Moirangthem T, Dhal MR, Pala S. Role of serum C-reactive protein and interleukin-6 as a predictor of intra-abdominal and surgical site infections after elective abdominal surgery. J Family Med Prim Care. 2021 Jan;10(1):403-406.

3. Longkumer C, Nath CK, Barman B, Ruram AA, Visi V, Yasir MD, Sangma MA. Idiopathic postprandial glucose-lowering, a whistleblower for subclinical hypothyroidism and insulin resistance. A cross-sectional study in Tertiary Care Centre of northeast India. J Family Med Prim Care. 2020 Sep 30;9(9):4637-4640.

4. Bhattacharyya H, Nath CK, Pala S, Medhi GK, Chutia H. Iodine Deficiency Disorders in Children in East Khasi Hills District of Meghalaya, India. Indian Pediatr. 2020; 57 (9): 811-14.

5. Nath CK, Barman B, Das A, Rajkhowa P, Baruah P, Baruah M, et al. Prolactin and thyroid-stimulating hormone affecting the pattern of LH/FSH secretion in patients with polycystic ovary syndrome: A hospital-based study from North East India. J Family Med Prim Care. 2019 Jan;8(1):256-60.

6. Sharma N, Nath CK, Mohammad J. Vitamin D status in pregnant women visiting a tertiary care center of North Eastern India. J Family Med Prim Care. 2019 Feb;8(2):356-60.

7. Baruah A, Sarma K, Barman B, Phukan P, Nath CK, Boruah P, et al. Clinical and Laboratory Presentation of Hydatid Disease: A Study From Northeast India. Cureus. 2020 Sep 5;12(9):e10260.

8. Barman B, Bora K, Nongpiur A, et al. Marijuana smoking: a possible cause of diffuse alveolar hemorrhage. Autos Case Rep [Internet]. 2020; 10(mês-mês):e2020174.

9. Nath CK, Barman B, Rajkhowa P, Sailo SL, Medhi PB, S Dutta et al. Estimation of Chemical Composition of Renal Stones: An Observational Study from a Tertiary Care Centre of North East India. Journal of Clinical and Diagnostic Research. 2019 Mar; 13(3): BC08-BC10

10. Nath CK, Rajkhowa P, Barman B, Barman H, Dutta A, Pala S, Bora K, Ahmed F, Boruah P, Baruah A. Plasma neutrophil gelatinase-associated lipocalin (NGAL): A candidate biomarker to detect early acute kidney injury (AKI) for at-risk intensive care admissions. J Family Med Prim Care. 2022 Jul;11(7):3681-3686. doi: 10.4103/jfmpc.jfmpc_2316_21. Epub 2022 Jul 22. PMID: 36387665.

অখিল ভাৰতীয় আয়ুৰ্বিজ্ঞান প্ৰতিষ্ঠান, গুৱাহাটী

अखिल भारतीय आयुर्विज्ञान संस्थान, गुवाहाटी

All India Institute of Medical Sciences, Guwahati

About Department

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2. Patient care

3. Research

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