department AIIMS Guwahati

About Department
Faculty Members

The Department of Biochemistry commenced its services since the inception of the Institute in January 2021. The vision of the Department is to develop into a state-of-the-art facility that caters to the three-pronged approach adopted by the AIIMS institutions viz. Education, Patient Care, and Research. The Department plans to achieve this in the following manner:

Education

The Department is committed to nurture students with advancements in Medical Biochemistry and to inculcate in them scientific curiosity, critical thinking, ethical attitudes, and practical skills. Besides the ongoing MBBS course, the Department envisions to start post-graduate courses and doctoral courses in Biochemistry and address the needs of the courses in allied specialties.

Patient care

The Department will actively support the Institute in patient care by providing the latest laboratory facilities to aid in diagnosis, monitoring, and prognosis. The services will range from routine lab tests in clinical biochemistry to sophisticated biomarker testing involving molecular diagnostics, genomics, and proteomics. The Department will specifically emphasize providing primordial and primary screening facilities for the diseases prevalent in the community.

Research

The Department is committed to perform health-oriented research and basic science research in the diverse fields of biomedical research such as cancer biology, cardiovascular diseases, metabolic diseases, molecular pharmacology, genomics, transcriptomics, medical genetics, newborn screening, prenatal screening, and data mining. This will be achieved independently as well as by collaborations with academic and research institutes involved in multidisciplinary research, within and outside India.

Dr. Subash Chandra Gupta

Additional Professor & Head of the Department

scgupta@aiimsguwahati.ac.in

Dr. Subash Chandra Gupta

Additional Professor & Head of the Department

Biochemistry

Qualifications

Ph.D. (Biochemistry): IITR (CSIR) Lucknow and University of Lucknow, India (2008)

M.Sc. (Biochemistry): University of Lucknow, India (2001)

Email

scgupta@aiimsguwahati.ac.in

Research interests/ Areas of Expertise/ Brief profile

Dr. Subash Gupta has contributed significantly to understanding the role of inflammatory pathways in cancer pathogenesis. His current research is focused on elucidating the role of long non-coding RNAs in the diagnosis and prognosis of cancer types such as breast cancer, head-and-neck cancer, gallbladder cancer, and glioblastoma. He has also been working to uncover the mechanism by which the acidic micro-environment contributes to cancer pathogenesis. He has published over 100 peer-reviewed articles in highly prestigious journals (total citations: >18,000; h index: 50; i10-index: 90; cumulative impact factor: 796.602; average impact factor: 7.96). He has supervised several masters and doctoral candidates.

Google Scholar link: https://scholar.google.com/citations?user=tCzrPS0AAAAJ&hl=en

ORCID id: https://orcid.org/0000-0002-0418-1940

ResearchGate link: https://www.researchgate.net/scientific-contributions/Subash-Chandra-Gupta-2119079541

Memberships

1. The National Academy of Sciences, India.

2. Indian Academy of Biomedical Sciences, India.

3. American Association for Cancer Research.

4. Society for Nutraceuticals and Chronic Diseases, India.

5. Indian Society of Cell Biology.

1. Highly Cited Researcher, Web of Science Group, Clarivate Analytics (2019, 2020).

2. Most Productive Researcher Award, Institute of Science, Banaras Hindu University, India (2018, 2019).

3. Shri Om Prakash Sharma Award, Indian Academy of Biomedical Sciences, India (2019).

4. Early Career Research Award by Science and Engineering Research Board, India (2016).

5. Dr. Prem Nath Wahi Award by Indian Council of Medical Research, India (2015).

6. AAPS Journal Manuscript Award (2015).

7. Novartis Oration Award by Indian Council of Medical Research, India (2014).

8. National Eligibility Test (CSIR-UGC-NET) by University Grants Commission, India (2003).

9. Junior Research Fellowship by Council of Scientific and Industrial Research, India (2002).

10. Junior Research Fellowship by Indian Council of Medical Research, India (2002).

Latest Publications

1. Shekher A, Tiwari AK, Awasthee N, Verma SS, Dixit VK, Sinha N, Gupta SC, Puneet. Genes involved in phosphatidylcholine biosynthesis correlate with nuclear factor-kB in biliary tract cancer patients: Evidence from 1H-NMR and computational analyses. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids 1866 (2021): 158970. 2020 IF: 4.698.

2. Aggarwal S, Verma SS, Aggarwal S, Gupta SC. Drug repurposing for breast cancer therapy: Old weapon for new battle. Seminars in Cancer Biology 68 (2021): 8-20. 2020 IF: 15.707.

3. Goyal B, Yadav SRM, Awasthee N, Gupta S, Kunnumakkara AB, Gupta SC. Diagnostic, prognostic, and therapeutic significance of long non-coding RNA MALAT1 in cancer. Biochimica et Biophysica Acta-Reviews on Cancer 1875 (2021): 188502. 2020 IF: 10.68.

4. Rai V, Aggarwal SK, Verma SS, Awasthee N, Dhasmana A, Aggarwal S, Das SN, Nair MS, Yadav S, Gupta SC. Epoxyazadiradione exhibit activities in head and neck squamous cell carcinoma by targeting multiple pathways. Apoptosis 25 (2020): 763-782. 2020 IF: 4.677.

5. Chava S, Reynolds PC, Pathania A, Gorantla S, Poluektova LY, Coulter DW, Gupta SC, Pandey MK, Challagundla KB. miR-15a-5p, miR-15b-5p, and miR-16-5p inhibits tumor progression by directly targeting MYCN in neuroblastoma. Molecular Oncology 14 (2020): 180-196. 2020 IF: 6.603.

6. Gupta SC, Awasthee N, Rai V, Gunda V, Chava S, Challagundla KB. Long non-coding RNAs and nuclear factor-kB crosstalk in cancer and other human diseases. Biochimica et Biophysica Acta-Reviews on Cancer 1873 (2020): 188316. 2020 IF: 10.68.

7. Verma SS, Rai V, Awasthee N, Dhasmana A, Rajalaksmi DS, Nair MS, Gupta SC. Isodeoxyelephantopin, a sesquiterpene lactone induces ROS generation, suppresses NF-kB activation, modulates lncRNA expression and exhibit activities against breast cancer. Scientific Reports-Nature 9 (2019): 17980. 2020 IF: 4.379.

8. Mishra S, Verma SS, Rai V, Awasthee N, Arya J, Maiti KK, Gupta SC. Curcuma raktakanda induces apoptosis and suppresses migration in cancer cells: Role of reactive oxygen species. Biomolecules 9 (2019): 4. 2020 IF: 4.879.

9. Awasthee N, Rai V, Verma SS, Francis KS, Nair MS, Gupta SC. Anti-cancer Activities of Bharangin Against Breast Cancer: Evidence for the Role of NF-kB and lncRNAs. Biochimica et Biophysica Acta-General Subjects 1862 (2018): 2738–2749. 2020 IF: 3.77.

10. Kumari S, Khan S, Gupta SC, Kashyap VK, Yallapu M, Jaggi M, Chauhan SC. MUC13 contributes to rewiring of glucose metabolism in pancreatic cancer. Oncogenesis 7 (2018): 19. 2020 IF: 7.485.

Books

1. Clinical applications of non-coding RNAs in cancer. Publisher: Elsevier Inc; 2021; in press.

2. Anti-inflammatory Nutraceuticals and Chronic Diseases. Series: Advances in Experimental Medicine and Biology; Publisher: Springer; 2016; Page 1-479.

3. Drug Discovery from Mother Nature. Series: Advances in Experimental Medicine and Biology; Publisher: Springer; 2016; Page 1-407.

4. Inflammation and Cancer. Series: Advances in Experimental Medicine and Biology; Publisher: Springer; 2014; Page 1-490.

Book chapters

1. Awasthee N, Shekher A, Rai V, Baruah PK, Sharma A, Challagundla KB, Gupta SC. Clinical significance of long non-coding RNAs in breast cancer patients. In: Clinical applications of non-coding RNAs in cancer, edited by Gupta SC, Challagundla KB, Elsevier Inc., Cambridge, MA, USA, 2021, in press.

2. Pathania AS, Smith OV, Prathipati P, Gupta SC, Challagundla KB. Clinical implications of non-coding RNAs in neuroblastoma patients. In: Clinical applications of non-coding RNAs in cancer, edited by Gupta SC, Challagundla KB, Elsevier Inc., Cambridge, MA, USA, 2021, in press.

3. Chauhan HS, Rai V, Kini S, Shekher A, Sharma A, Gupta SC. Potential of long non-coding RNAs in the diagnosis and therapy of melanoma skin cancer. In: Skin cancer: Pathogenesis and Diagnosis, edited by Dwivedi A, Tripathi A, Ray RS, Singh AK, Springer Nature Singapore Pte Ltd, Singapore, 2021, in press.

4. Dwivedi S, Verma SS, D’Souza C, Awasthi N, Sharma A, Gupta SC. Potential of Small Animals in Toxicity Testing: Hope from Small World. In: Biomarkers in Toxicology 2e, edited by Gupta RC, Elsevier Inc., San Diego, USA, 2019, Chapter 7, pp 129-142.

5. Verma SS, Rai V, Shukla KK, Gupta SC. Regulation of non-coding RNAs by phytochemicals for cancer therapy. In: Nutritional Epigenomics, edited by Ferguson BS, Elsevier Inc., San Diego, USA, 2019, Chapter 22, pp 371-380.

6. Sharma A, D’Souza C, Rai V, Gupta SC. Evaluation of safety and efficacy of nutraceuticals using Drosophila as an in vivo tool. In: Nutraceuticals in Veterinary Medicine, edited by Gupta R, Srivastava A, Lall R, Springer Press, Spring Street, NY, USA, 2019, pp 685-692.

7. Gupta SC, Sharma A, Mishra S, Awasthee N. Nutraceuticals for the Prevention and Cure of Cancer. In: Nutraceuticals in Veterinary Medicine, edited by Gupta R, Srivastava A, Lall R, Springer Press, Spring Street, NY, USA, 2019, pp 603-610.

8. Mishra S, Rai V, Kumar A, Aggarwal SK, Gupta SC. Molecular diagnostics in pancreatic cancer. In: Molecular Diagnostics in Cancer Patients, edited by Shukla K, Sharma P, Misra S, Springer Nature Singapore, 2019, pp 157-163.

9. Gupta SC, Rai V. Role of Emodin in Chemosensitization of Cancer. In: Role of Nutraceuticals in Cancer Chemosensitization, edited by Bharti AC and Aggarwal BB, Elsevier Inc., Philadelphia, USA, 2018, Chapter 12, pp 241-257.

10. Gupta SC, Kim JH, Prasad S, Aggarwal BB. Chronic inflammation and cancer: a matter of lifestyle. In: Chronic Inflammation: Molecular Pathophysiology, Nutritional and Therapeutic Interventions, edited by Roy S, Bagchi D, Raychaudhuri SP. CRC Press, Taylor and Francis Group, Boca Raton, NY, 2012, pp. 153-171.

Dr. Jayanta Das

Associate Professor

jayantadas@aiimsguwahati.ac.in

Dr. Jayanta Das

Associate Professor

Biochemistry

Qualifications

MBBS: 1998

MD: 2005

Email

jayantadas@aiimsguwahati.ac.in

Research interests/ Areas of Expertise/ Brief profile

Interested in clinical biochemistry and health-oriented research.

Memberships

Life member of Assam Chapter - Association of Medical Biochemists of India (AMBI).

1. Certificate of Appreciation for professional excellence at Dr. B. Borooah Cancer Institute, Assam (2009).

1. Jayanta Das, Dibyaratna Patgiri, Nirmali Mattack, Elteza Tahjiba Jahir. A Study on the Biological Reference Interval of Vitamin D in North-East India. National Journal of Laboratory Medicine. 2019 Apr, V0l-8(2): BO01-BO04.

Dr. Amit Kumar Sonkar

Assistant Professor

amitsonkar@aiimsguwahati.ac.in

Dr. Amit Kumar Sonkar

Assistant Professor

Biochemistry

Qualifications

Email

amitsonkar@aiimsguwahati.ac.in

Research interests/ Areas of Expertise/ Brief profile

Memberships

Dr. Ashikh Seethy

Assistant Professor

ashikhseethy@aiimsguwahati.ac.in

Dr. Ashikh Seethy

Assistant Professor

Biochemistry

Qualifications

ICSE: 2004 - St. Pius X English School, Kuttikanam, Kerala

ISC: 2006 - Alphonsa Residential School, Bharananganam, Kerala

MBBS: 2013 - Malankara Orthodox Syrian Church Medical College, Cochin

MD (Biochemistry): 2016 - Maulana Azad Medical College, New Delhi

DNB (Biochemistry): 2017 - National Board of Examinations, New Delhi

PhD (Biochemistry): Pursuing (due 2021) - All India Institute of Medical Sciences, New Delhi

Email

ashikhseethy@aiimsguwahati.ac.in

Research interests/ Areas of Expertise/ Brief profile

Dr. Ashikh Seethy has a research interest in genomics, medical genetics, cancer biology, and data mining. He has completed several workshops in the field of genetics and genomics. He is the Associate Editor and a chapter author of Lippincott Illustrated Reviews – Biochemistry, South Asian Edition. He is also a resource person in online courses like SWAYAM and e-PG-Pathshala by the Government of India. He is trained in advanced techniques like gene editing and next-generation sequencing and has been involved in Molecular Biology training as a part of numerous workshops.

PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=ashikh+seethy&sort=date

ResearchGate: https://www.researchgate.net/profile/Ashikh-Seethy

Scholar: https://scholar.google.com/citations?user=6zAHBkAAAAAJ&hl=en

LinkedIn: https://www.linkedin.com/in/ashikhseethy/

ORCID: https://orcid.org/0000-0001-6825-5753

Memberships

1. Lifetime membership in American Association for Clinical Chemistry - India Session.

2. Lifetime membership in India Society of Atherosclerosis Research – Delhi Chapter.

3. Membership in the Society of Young Scientists – AIIMS, New Delhi.

4. Lifetime membership in the Association of Medical Biochemists of India.

1. All India Rank-1 in the specialty of Biochemistry in the first attempt in the National Eligibility and Entrance Test for Medical Super Speciality Courses in India (NEET-SS) in June 2017.

2. All India Rank 7 in the specialty of Medical Genetics (DM/DNB-SS) in the National Eligibility and Entrance Test for Medical Super Speciality Courses in India (NEET-SS) in September 2020.

3. First place in FOUR national quiz competitions during residency: AMBICON – 2014 & 2015, ACBICON 2015, ISARCON 2019.

4. Best Oral Presentation Prize at the International Conference of Stem Cells and Cancer, Pune in October 2015 for the presentation titled ‘Tight Junction Protein, Claudin-6, is Downregulated in Human Breast Adenocarcinoma Cell Line, T47D and in Breast Cancer Tissues’.

5. Award Presentation Prize at the National Conference of Association of Medical Biochemists of India (AMBICON) in November 2015 for the paper titled ‘Decreased TET1 Mediated Hydroxymethylation of Promoter CpG Islands Causes Downregulation of Tight Junction Protein, Claudin-6 in Breast Adenocarcinoma Cells’.

6. Poster Presentation Prize at the National Conference of Association of Medical Biochemists of India (AMBICON) in December 2019 for the poster titled ‘What drives the progression of Myelodysplastic Syndromes to Acute Myeloid Leukemia?’

7. Quizmaster (3 times) for State Level Quiz on Immunology for MBBS Students/ Postgraduates/ Doctoral students - Organised by Indian Immunology Society and AIIMS, New Delhi – 2017, 2018, and 2019.

8. All India Rank-1 Ph.D. Program Entrance Exam, and Senior Residents Recruitment Exam (Biochemistry) by AIIMS-New Delhi, in July 2016.

9. Best Journal Club presentation award by the Department of Biochemistry, All India Institute of Medical Sciences, New Delhi for the year 2017.

10. Acknowledged as a Reviewer in the textbook ‘Biochemistry – Stryer': 8th ed and 9th ed, one of the most accepted textbooks in the subject.

1. Seethy A, Singh S, Mukherjee I, Pethusamy K, Purkayastha K, Sharma JB, et al. Potential SARS-CoV-2 interactions with proteins involved in trophoblast functions – An in-silico study. Placenta. 2021 Jan 1;103:141–51.

2. Seethy A, Pethusamy K, Chattopadhyay I, Sah R, Chopra A, Dhar R, et al. TETology: Epigenetic mastermind in action. Appl Biochem Biotechnol. 2021 Mar 10. DOI: 10.1007/s12010-021-03537-5.

3. Dhar R, Seethy A, Pethusamy K, Singh S, Rohil V, Purkayastha K, et al. De novo assembly of the Indian blue peacock (Pavo cristatus) genome using Oxford Nanopore technology and Illumina sequencing. Gigascience. 2019 01;8(5).

4. Pethusamy K*, Seethy A*, Kulandhasamy M, Garg P, Chowdhury D, Agarwal S, et al. Effects of 469 E/K polymorphism of ICAM1 gene in ischemic stroke and its association with stroke severity and outcome. AJMS 2021 Jan;12(1) *Equal contribution as the first author.

5. Dhar R, Seethy A, Singh S, Pethusamy K, Srivastava T, Talukdar J, et al. Cancer Immunotherapy: Recent Advances and Challenges. Journal of Clinical Research and Therapeutics (in print).

6. Chattopadhyay I, Dhar R, Pethusamy K, Seethy A, Srivastava T, Sah R, Sharma J, Karmakar S. Exploring the Role of Gut Microbiome in Colon Cancer. Appl Biochem Biotechnol. 2021 Jan 25. DOI: 10.1007/s12010-021-03498-9.

7. Dhar R, Pethusamy K, Singh S, Mukherjee I, Seethy A, Sengupta B, et al. Draft genome of Ompok bimaculatus (Pabda fish). BMC Res Notes. 2019 Dec 26;12(1):825.

8. Dhar R, Jee B, Pethusamy K, Seethy A, Kumar A, Karmakar S. The scars of COVID19: Preparing for the collateral damages. AJMS 2020 Nov;11(6).

9. Dhar R, Sinha AY, Seethy A, Matta SA, Pethusamy K, Srivastava T, et al. Genotypic and antigenic study of SARS-CoV-2 from an Indian isolate. The preprint of this paper is available at bioRxiv. 2020 Jun 14;2020.06.10.140657.

Book chapters

1. Ashikh Seethy. Free Radicals, Oxidative Stress, and Antioxidant Defense Mechanism. In: Ferrier DR, Singh R, Goyal R, editors. Lippincott Illustrated Reviews: Biochemistry. SAE ed. New Delhi. Wolters Kluwer;2020.

2. Ashikh Seethy. Acid-Base Balance and Arterial Blood Gas (ABG) Analysis. In: Ferrier DR, Singh R, Goyal R, editors. Lippincott Illustrated Reviews: Biochemistry. SAE ed. New Delhi. Wolters Kluwer;2020.

3. Ashikh Seethy. Xenobiotics. In: Ferrier DR, Singh R, Goyal R, editors. Lippincott Illustrated Reviews: Biochemistry. SAE ed. New Delhi. Wolters Kluwer;2020.

4. Ashikh Seethy. Organ Function Tests. In: Ferrier DR, Singh R, Goyal R, editors. Lippincott Illustrated Reviews: Biochemistry. SAE ed. New Delhi. Wolters Kluwer;2020.

5. Ashikh Seethy. Water and Electrolyte Balance of Body Fluids. In: Ferrier DR, Singh R, Goyal R, editors. Lippincott Illustrated Reviews: Biochemistry. SAE ed. New Delhi. Wolters Kluwer;2020.

6. Ashikh Seethy. Ray PC. Cell Culture. In Bhat AA, Mir AR, editors. Quick Revision of Molecular Biology. New Delhi. Advance Research Publications; 2016.

7. Ashikh Seethy. Cellular Differentiation; Cellular and Molecular Biophysics. In PGPathshala-Biophysics. 2018. Accessible at: http://epgp.inflibnet.ac.in/epgpdata/uploads/epgp_content/S001174BS/P001859/M030469/ET/1526645528P11_M08_ET.pdf

8. Ashikh Seethy. Aging and Longevity; Cellular and Molecular Biophysics. In PGPathshala-Biophysics. 2018. Accessible at: https://epgp.inflibnet.ac.in/view_f.php?category=1859

9. Ashikh Seethy. Sequencing Techniques of Nucleic Acids. In SWAYAM: Ministry of Human Resources Development - Government of India. 2019. Accessible at: https://swayam.gov.in/nd2_ugc19_bt16/preview.

10. Seethy A., Karmakar S., Pethusamy K. (2019) Ontogeny. In: Vonk J., Shackelford T. (eds) Encyclopedia of Animal Cognition and Behavior. Springer, Cham. DOI: https://doi.org/10.1007/978-3-319-47829-6_526-1. (Encyclopedia article)

Dr. Chandan Kumar Nath

Assistant Professor

chandannath@aiimsguwahati.ac.in

Dr. Chandan Kumar Nath

Assistant Professor

Biochemistry

Qualifications

MD: 2008

Email

chandannath@aiimsguwahati.ac.in

Research interests/ Areas of Expertise/ Brief profile

Diagnostic research.

Memberships

1. Life member of Association of Medical Biochemists of India (AMBI).

1. Nath CK, Barman B, Phukan P, Sailo SL, Dey B, Nath I, Rajkhowa P. Prostate-Specific Antigen Density: A Measurement to Differentiate Benign Hypertrophy of Prostate from Prostate Carcinoma. J Lab Physicians. 2020 Mar;12(1):44-48.

2. Hajong R, Newme K, Nath CK, Moirangthem T, Dhal MR, Pala S. Role of serum C-reactive protein and interleukin-6 as a predictor of intra-abdominal and surgical site infections after elective abdominal surgery. J Family Med Prim Care. 2021 Jan;10(1):403-406.

3. Longkumer C, Nath CK, Barman B, Ruram AA, Visi V, Yasir MD, Sangma MA. Idiopathic postprandial glucose-lowering, a whistleblower for subclinical hypothyroidism and insulin resistance. A cross-sectional study in Tertiary Care Centre of northeast India. J Family Med Prim Care. 2020 Sep 30;9(9):4637-4640.

4. Bhattacharyya H, Nath CK, Pala S, Medhi GK, Chutia H. Iodine Deficiency Disorders in Children in East Khasi Hills District of Meghalaya, India. Indian Pediatr. 2020; 57 (9): 811-14.

5. Nath CK, Barman B, Das A, Rajkhowa P, Baruah P, Baruah M, et al. Prolactin and thyroid-stimulating hormone affecting the pattern of LH/FSH secretion in patients with polycystic ovary syndrome: A hospital-based study from North East India. J Family Med Prim Care. 2019 Jan;8(1):256-60.

6. Sharma N, Nath CK, Mohammad J. Vitamin D status in pregnant women visiting a tertiary care center of North Eastern India. J Family Med Prim Care. 2019 Feb;8(2):356-60.

7. Baruah A, Sarma K, Barman B, Phukan P, Nath CK, Boruah P, et al. Clinical and Laboratory Presentation of Hydatid Disease: A Study From Northeast India. Cureus. 2020 Sep 5;12(9):e10260.

8. Barman B, Bora K, Nongpiur A, et al. Marijuana smoking: a possible cause of diffuse alveolar hemorrhage. Autos Case Rep [Internet]. 2020; 10(mês-mês):e2020174.

9. Nath CK, Barman B, Rajkhowa P, Sailo SL, Medhi PB, S Dutta et al. Estimation of Chemical Composition of Renal Stones: An Observational Study from a Tertiary Care Centre of North East India. Journal of Clinical and Diagnostic Research. 2019 Mar; 13(3): BC08-BC10

অখিল ভাৰতীয় আয়ুৰ্বিজ্ঞান প্ৰতিষ্ঠান, গুৱাহাটী

अखिल भारतीय आयुर्विज्ञान संस्थान, गुवाहाटी

All India Institute of Medical Sciences, Guwahati

About Department

Faculty Members

Education

Patient care

Research